The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor γ and Its Therapeutic Modulation

Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome.

Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Three PPAR isoforms, designated PPARalpha, -beta/delta, and -gamma, have been identified and attracted enormous attention as a result of the key role that these receptors play in regulating adipogenesis, lipid metabolism, insulin sensitivity, infl...

Peroxisome Proliferator-Activated Receptor

Peroxisome proliferator - activated receptor

The peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor superfamily. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. The discovery of PPARγ as a target of multimodal insulin sensitizers has attracted remarkable scientific interest and had a great impact on the pharmaceutical industry. Thi...

Peroxisome Proliferator-Activated Receptor

Effect of peroxisome proliferator-activated receptor γ on inflammatory markers

Introduction In a recent study published in “ARYA atherosclerosis,” Pourmoghaddas et al. reported that administration of pioglitzone in non-diabetic patients with metabolic syndrome had no positive effect on inflammatory markers including high sensitive C-reactive protein, interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α).1 Peroxisome proliferator-activated receptors (PPARs) are ligan...